Welcome

Welcome to the Principles and Practice of Clinical Research Journal. This is an Official journal of the Principles and Practice of Clinical Research program affiliated to the ECPE Harvard TH Chan School of Public Health and an Official Journal of the Scala Institute Association. The Principles and Practice of Clinical Research is journal dedicated to disseminating cutting-edge clinical research evidence. As a peer-reviewed scientific journal, we aim to foster the exchange of knowledge among researchers, academicians, and professionals. Globalization has contributed significantly to the dissemination of information in different areas of knowledge. Scientific papers are therefore the way to contribute to this global debate and advance in science. 

PPCR journal will therefore contribute to disseminate the latest research and updates on clinical research.

PPCR journal aims to provide a medium for the publication of scientific articles of high quality, thus promoting the work and training of clinical researchers globally. 

This is a Free Open Access Journal, it is initially expected to be quarterly and open for new submissions.

Send your scientific article!

Check out the rules for submission. As the journal aims to be an international publication, all information and article submission should be formatted in English.

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Editor-in-Chief:
 
Felipe Fregni + Seguir Algo deu errado. Tente fazer sua solicitação  novamente mais tarde. OK Livros de Felipe Fregni 1 61 1 The Questions and  Answers Book on Statistics for Clinical Researchers: 262 questions for  deeper statistical The Cartoon Guide to ...
 
Professor Felipe Fregni, MD, PhD, MMSc, MPH

Managing Editors:
 
Mustafa Reha Dodurgali, MD

Online ISSN: 2378-1890

Metrics:
H-index - 3

Indexed in:
Google Scholar
Science Gate -  https://www.sciencegate.app/source/1713572797

License: CC BY 4.0
Copyright – Dustin Tyler Joyce

Vol. 11 No. 4 (2025): (In Press) Principles and Practice of Clinical Research

Published: 2026-04-26

Digestive Supplement Use and Abdominal Pain Among U.S. Adults: A Survey-Weighted Analysis of NHANES 2017–2018

Susy Cedeno Arevalo, Maria Lucia Andrews, Tanya Mateo, Branda Arismendy, Luisa Cruz, Andres Gomez, Raphaela Anderson Colares, Daniel Villareal, Daniela Godoy, Oludolapo Omoyiola, Shailza Kathuria, Camila Schumacher Kluge, Yasmim Helen Dias de Souza, Abisoye Ajayi, Jerry Li, Aline Fares, Beatriz Bartulic Machado, Natalia Soto, Hebe Castillo Molina, Alessandro Solis, Giannina Melgarejo, Dorcas Thairu, Oluwatosin Ajibola, Erica Adissy, Ahmed Salem Alsuliamani, David Rodriguez, Ana Fandinho, Federica Rossetto

Association Between Self-Reported Diabetic Diet and LDL Cholesterol Levels in U.S. Overweight and Obese Adults: A Cross-Sectional Analysis of NHANES 2017–2018

Roberto Segura, Angela Quinche, Alanna Michel Zorrilla Marte, Aarti Garg, Anushka Verma, Arthur de Ávila, Arthur Gomes Oliveira Braga, Brian Villafuerte-Trisolini, Drumadala Gajbhiye, Elif Kortan, Enkhtuul Iderjavkhlan, Fernanda Mishelly Yánez Llerena , Gabrielle Sigaki, Giulia Soares, Josefina Maria Bran, Lucas Caro Herrera, Manuela Neira, Maria Guadalupe Gomez-Castano, Nathalia Serrato, Nicole Schleicher, Pedro Jara-Guajardo, Renzo Villagra, Ruzika Puljic, Sherin Rahim, Stefano Doronzio, Sulaiman Abubakar, Waleed El Harith, Walter Marrou

Association Between Caffeine Intake and Depressive Symptoms: A Cross-sectional Analysis Using the NHANES 2017-2018 Database

Marion Feddersen Welkner, Jorgelina Stegmann, Miray Nilufer Cimsit Kemahli, Diego Perez Paez, Hanna Bennewart, Laura Amaral de Lara Resende, Fernando Espinoza, Paula Aranguren, Paula Bertagnoli, Sarah Burgos, Nikolaos Paschos, Carlos Roa, Natália Puschnick Gimenez, Letícia Cabreira dos Santos, Lissa Raquel Sandoval Castillo, Karla Andrade Ruiz, Siddiha Poovelil Shahulhameed, Paulina Troncoso Escudero, Priscila Sales Barroso, Yulissa Hernández Frías, Daniela Vicinansa Monaco Ferreira, Ala Hassan, Henrique Balseiro Zin, Alice Campanholo de Oliveira, Jae Kyung Jo, Fernando Jose Gomez Juarez, Roy Rosado

Open-Label Placebo Effects in Reducing Depression Severity Among Adults with Major Depressive Disorder: A Systematic Review and Meta-Analysis of Early Evidence

Janet Mercedes Arévalo-Ipanaqué, Maria Leticia Gobo Silva, Ricardo Romero-Vucovich, Gianluca Conte, Matheus Gerhard Rosenfeld, Sergio José Fausto Girón, Lisa Gonzalez, Jordy Batista, Sofia Ines Volpi, Maximiliano Espinosa, Daniela Lorena Alvarado Rodriguez, Salvatore Minnella, Tadeus Lopez Ulloa, Nadine Aranis Seguic, Yazmin Heredia Allegretti, Johan Antonio De La Rosa Laureano, Cristian Camilo Bermudez, Letícia Watanabe Koyama, Maria Eduarda Nabhan de Souza, Somaya Althobaiti, Karen Gamonal, Folasade Mary Adeyemi, Luis Pedro Lorenzana, Aderibigbe Adeniyi Sheriff, Peter Benedek, Wajih jawhar

Caffeine, Alcohol, and Tobacco Use in Shift-Working Healthcare Professionals: A Systematic Review

Elizabeth Cramer Jenkins, Riani Ananda Nunes Soares, Andrea Giansante Barros, Alexandra Nedelusi, Aline Ferreira de Mello, Alvaro Marroquin Murcia, Amanda Doerksen, Ana Paula Solorzano Anduiza, Annette Alexandra Orosco Figueroa, Charisse Brunelle Fernandez, Debora Duarte Gonçalves, Felipe Xavier Camargo, Helisandro Montenegro Brandao, Henrique Furlan Pauna, Isabel Pichardo, Jainer Jose Mendez Florez, Jose Fernando Arriaga Ibargüen, Juana Vasquez Rodas, Juliana Vieira de Oliveira Salerno, Matheus Machado Berleze, Rais Pokharel, Vania Torres Palacios, Ximena Gomez, Sofia Peña Romero

Effects of Long-term Aerobic or Resistance Exercise on Chronic Inflammatory Markers in Overweight or Obese Postmenopausal Women: A Systematic Review of Controlled Clinical Trials

Emi Kosa Zerzan, Tope Olubodun, Laura Wollborn, Fabiana Nuccetelli, Mary Joe Esquivel Romero, Daniela Santibañez, Elisa Benicio Henriques, Manuel Zeledon Ramirez, Natalia Maria Bim de Oliveira, Maria Milagros Rojas Cardenas, Franchely Rosario, Monica Freire Bermudez, Giulia Beloumini Valencia, Joo-Hee Kim, Valeria Loja Pauta, Giovanna Milanes Bego Soares, Ahmet Toygun Yildirim, Paula Duarte D'Ambrosio, Daniela Barros de Oliveira , Cesar Burgos Jimenez, Cecilia Alva Pacheco, Blerta Budani, Camila Silva Alfaro, Taraf Alshammari, Pedro José Esquivel Velásquez , Izadora Brambila Stanguerlin, Lavinia Rech, Julia R. Garcia

Effects of the Mediterranean Diet on Gut Microbiota Composition and Diversity in Overweight and Obesity: A Scoping Review of Randomized Controlled Trials

Alanna Michel Zorrilla Marte, Angela Quinche, Gabrielle Sigaki, Giulia Soares, Josefina Maria Bran, Nathalia Serrato , Aarti Garg, Anushka Verma, Arthur de Ávila, Arthur Braga, Brian Villafuerte-Trisolini, Drumadala Gajbhiye, Elif Kortan, Enkhtuul Iderjavkhlan, Fernanda Mishelly Yánez Llerena , Lucas Caro Herrera, Manuela Neira, Maria Guadalupe Gomez-Castano, Nicole Schleicher, Pedro Jara-Guajardo, Pedro Henrique Faria, Renzo Villagra, Roberto Segura-Retana, Ruzika Puljic, Sherin Rahim, Stefano Doronzio, Sulaiman Abubakar, Waleed El Harith

Caffeine and Cognitive Performance in Healthy Adults: Domain-Specific Effects and Dosing Considerations

Paulina Troncoso-Escudero, Marion Erica Feddersen Welkner, Jae Kyung Jo, Daniela Vicinansa Monaco Ferreira, Karla Andrade Ruiz, Fernando Jose Gomez Juarez, Natália Puschnick Gimenez, Jorgelina Stegmann, Henrique Balseiro Zin, Alice Campanholo de Oliveira, Yulissa Hernández Frías, Lissa Raquel Sandoval Castillo, Miray Nilufer Cimsit Kemahli, Priscila Sales Barroso, Diego Perez Paez, Letícia Cabreira dos Santos, Hanna Bennewart, Laura Amaral de Lara Resende, Siddiha Poovelil Shahulhameed, Fernando Espinoza, Paula Aranguren, Paula Bertagnoli, Sarah Burgos, Ala Hassan, Nikolaos Paschos, Carlos Roa, Roy Rosado

Design Considerations for Clinical Trials Combining Music Therapy and Physical Activity in Alzheimer’s Disease: Lessons from designing a Multicenter Randomized Protocol

Alice Liriano, Ana Isabella Bencosme, Angélica Furzán, Bruno Cateb, Carla Arias, Carolina Matté Dagostini, Claudia Meireles, Daniel Musse Gomes, Daniela Jorquera, David Moros, Erlando Mendez, Giovanna Oliveira dos Santos, Hanan Alshareef, Jazmin Insfran, Jorge Pastrana, Komwudh Konchalard, Lucas Koji Uchiyama, Marcos Brioschi, Marcos Ramirez, Mario Diego Teles Correia, Matheus Machado Rech, Mayra Muñoz, Natalia Rodriguez, Nelia Sanchez-Crespo, Nicole Mannis, Olumide Adeniyi, Pascal Gaechter, Rodrigo Mariano, Silvia Castro Piedra, Tatiana Dus
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